Santos Filho, Paulo Samuel Santos, Marisa Colafranceschi, Alexandre Siciliano Pragana, Andrea Nunes de Souza Correia, Marcelo Goulart Simões, Heloisa Helena Rocha, Fernando Alves Soggia, Maria Eduarda de Vasconcelos Santos, Ana Paula Malta Samuel Coutinho, Annie de Azeredo Figueira, Matheus Swarovsky Tura, Bernardo Rangel Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial <div><p>Abstract Objective: To evaluate the efficacy of triclosan-coated suture for the reduction of infection in saphenectomy wounds of patients undergoing coronary artery bypass graft (CABG) surgery. Methods: A total of 508 patients who underwent saphenectomy in CABG surgery were included in a prospective, randomized, double-blind trial from February/2011 to June/2014. Patients were randomized into the triclosan-coated suture group (n= 251) and the conventional non-antibiotic suture group (n=257). Demographic (gender and age), clinical (body mass index, diabetes, and use of analgesics), and intraoperative (cardiopulmonary bypass and cross-clamp times) variables and those related to the saphenectomy wound (pain, dehiscence, erythema, infection, necrosis, and hyperthermia) were measured and analyzed. Results: Of the 508 patients who underwent saphenectomy, 69.9% were males and 40.2% were diabetic. Thirty-three (6.5%) patients presented infection: 13 (5.3%) with triclosan and 20 (7.9%) with conventional suture (P=0.281). Among diabetic patients (n=204), triclosan suture was used in 45.1% with four cases of infection; conventional suture was used in 54.9% of them, with 11 cases of infection. Most patients (94.3%) underwent on-pump CABG. Wound pain was observed in 9.9% of patients with triclosan-coated suture and in 17.9% with conventional suture (P=0.011). Wound hyperthermia was found in 1.6% of patients with triclosan-coated suture and in 5.4% of those with conventional suture (P=0.028). Conclusion: Triclosan-coated suture shows lower infection rate in saphenectomy of patients undergoing CABG, although the differences were not statistically significant. Pain and wound hyperthermia were less frequent in patients with triclosan-coated sutures compared with conventional sutures.</p></div> Wound Infection;Sutures;Triclosan;Coronary Artery Bypass Graft;Cardiopulmonary Bypass;Erythema;Body Mass Index;Analgesics;Pain 2019-11-13
    https://scielo.figshare.com/articles/dataset/Effect_of_Using_Triclosan-Impregnated_Polyglactin_Suture_to_Prevent_Infection_of_Saphenectomy_Wounds_in_CABG_A_Prospective_Double-Blind_Randomized_Clinical_Trial/10295924
10.6084/m9.figshare.10295924.v1