LIN, San-Chi CHAGNAADORJ, Amarzaya BAYARSENGEE, Uyanga LEUNG, Ting-Kai CHENG, Chao-Wen The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy <div><p>Abstract The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protective effect of DADS on doxorubicin (Dox)-induced nephrotoxicity and its potential regulation of the Nrf2 pathway. Treatment with DADS (200 μM) induced heme oxygenase (HO)-1 and NADPH quinone oxidoreductase 1 (NQO-1) expression in a human proximal tubular cell line. The induction of HO-1 expression was suppressed in Nrf2-silenced cells. In an animal study, pretreatment with DADS relieved Dox-induced albuminuria, increased catalase activity, and reduced the urinary 8-hydroxy-2'-deoxyguanosine level. In addition, DADS ameliorated the severity of glomerulosclerosis and suppressed expressions of fibrotic and inflammatory gene expressions. Our data indicate that DADS, a major component of garlic, showed protective effects of preventing the progression of Dox-induced nephropathy through enhancing Nrf2-mediated antioxidant activity. DADS, a normal constituent of the human diet, merits investigation as a potential antioxidant daily food supplement against free radical-mediated chronic diseases.</p></div> 8-Hydroxy-2'-deoxyguanosine;catalase;heme oxygenase 1;nuclear factor erythroid 2-related factor 2;organosulfur compounds 2019-12-04
    https://scielo.figshare.com/articles/dataset/The_compound_diallyl_disulfide_enriched_in_garlic_prevents_the_progression_of_doxorubicin-induced_nephropathy/11313437
10.6084/m9.figshare.11313437.v1