10.6084/m9.figshare.11966100.v1 Fabio Mendonça Xavier Andrade Fabio Mendonça Xavier Andrade Fabiola Rosa Picosse Fabiola Rosa Picosse Laura Pires da Cunha Laura Pires da Cunha Camila Maia Valente Camila Maia Valente Fernanda Machado Bezerra Fernanda Machado Bezerra Helio Miot Helio Miot Edileia Bagatin Edileia Bagatin Denise de Freitas Denise de Freitas Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline SciELO journals 2020 Rosacea/drug therapy Doxycycline/therapeutic use Doxycycline/administration & dosage Isotretinoin/the rapeutic use Isotretinoin/administration & dosage Ocular sur face Blepharitis 2020-03-11 02:45:31 Dataset https://scielo.figshare.com/articles/dataset/Ocular_surface_changes_in_the_treatment_of_rosacea_comparison_between_low-dose_oral_isotretinoin_and_doxycycline/11966100 <div><p>ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was > 20/30 in >90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p<0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin.</p></div>