Does infection by the hepatitis C virus decrease the response of immunization against the hepatitis B virus in individuals undergoing dialysis?
Tarcila Maria Bonfim Ferreira
Tácio Giordano Santana Guimarães
Andrea Martins Melo Fontenele
Natalino Salgado Filho
Adalgisa de Souza Paiva Ferreira
Alessandra Porto de Macedo Costa
10.6084/m9.figshare.5670160.v1
https://scielo.figshare.com/articles/dataset/Does_infection_by_the_hepatitis_C_virus_decrease_the_response_of_immunization_against_the_hepatitis_B_virus_in_individuals_undergoing_dialysis_/5670160
<div><p>Abstract Introduction: Vaccination is the most effective tool in preventing transmission of Hepatitis B Virus (HBV). The patient with chronic kidney disease (CKD) on dialysis appear to be at greater risk of becoming infected with this virus and does not show the same vaccine response when compared to patients without uremia. Objectives: To evaluate the results related to the HBV vaccine and identify factors associated with the response in patients with CKD on hemodialysis. Methods: Individuals with HBsAG and negative anti-HBC, under hemodialysis were assessed in two units of São Luis, Maranhão and were undergone full vaccination schedule for HBV. They were divided in groups: anti-HBs10 mUI/mL and compared as to age, gender, presence of diabetes mellitus (DM), time on dialysis and anti-HCV status. Logistic regression analysis was performed to identify factors independently associated with the vaccine response. p10mUI/Ml (or = 5.239 IC: 1.279-21.459, p = 0.021). Conclusion: The rate of vaccine response to HBV in patients with CKD on dialysis was 70% and the lack of anti-HCV infection was associated with seroconversion of anti-HBs suggesting that infection by the hepatitis C virus may be a factor that decreases the response of the HBV vaccine in dialysis CKD patients.</p></div>
2017-12-05 14:38:12
hepatites B vacines
hepatites B vírus
hepatitis C
renal insufficiency, chronic
vaccination
hepatite C
insuficiência renal crônica
vacinação
vacinas contra hepatite B
vírus da hepatite B