10.6084/m9.figshare.5815980.v1
André Castagna Wortmann
André Castagna
Wortmann
Daniel Simon
Daniel
Simon
Luiz Edmundo Mazzoleni
Luiz Edmundo
Mazzoleni
Guilherme Becker Sander
Guilherme Becker
Sander
Carlos Fernando de Magalhães Francesconi
Carlos Fernando de Magalhães
Francesconi
Débora Dreher Nabinger
Débora Dreher
Nabinger
Camila Schultz Grott
Camila Schultz
Grott
Tássia Flores Rech
Tássia Flores
Rech
Felipe Mazzoleni
Felipe
Mazzoleni
Vagner Ricardo Lunge
Vagner Ricardo
Lunge
Laura Renata de Bona
Laura Renata de
Bona
Tobias Cancian Milbradt
Tobias Cancian
Milbradt
Themis Reverbel da Silveira
Themis Reverbel da
Silveira
The association between adult-type hypolactasia and symptoms of functional dyspepsia
SciELO journals
2018
bloating
dyspepsia
gastrointestinal diseases
lactose intolerance
single nucleotide polymorphism
2018-01-24 02:40:14
Dataset
https://scielo.figshare.com/articles/dataset/The_association_between_adult-type_hypolactasia_and_symptoms_of_functional_dyspepsia/5815980
<div><p>Abstract Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia.</p></div>