Monteiro, Jean M.C. San-Martin, Daniel L. Silva, Beatriz C.G. Jesus, Pedro A.P. de Oliveira Filho, Jamary Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke <div><p>ABSTRACT Objectives To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). Methods A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Results Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments). Conclusion Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding.</p></div> Chagas disease;warfarin;stroke;atrial fibrillation 2018-01-24
    https://scielo.figshare.com/articles/dataset/Anticoagulation_in_patients_with_cardiac_manifestations_of_Chagas_disease_and_cardioembolic_ischemic_stroke/5816025
10.6084/m9.figshare.5816025.v1