%0 Generic %A Bouabdallaoui, Nadia %A Demondion, Pierre %A Maréchaux, Sylvestre %A Varnous, Shaida %A Lebreton, Guillaume %A Mouquet, Frédéric %A Leprince, Pascal %D 2018 %T Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience %U https://scielo.figshare.com/articles/dataset/Heart_Transplantation_for_Peripartum_Cardiomyopathy_A_Single-Center_Experience/5907706 %R 10.6084/m9.figshare.5907706.v1 %2 https://scielo.figshare.com/ndownloader/files/10538392 %2 https://scielo.figshare.com/ndownloader/files/10538401 %2 https://scielo.figshare.com/ndownloader/files/10538440 %2 https://scielo.figshare.com/ndownloader/files/10538443 %K Heart Failure %K Cardiomyopathies / mortality %K Peripartum Period %K Heart Transplantation %K Graft Rejection. / mortality %X

Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.

%I SciELO journals