Acute kidney injury and intra-abdominal hypertension in burn patients in intensive care Thalita Bento Talizin Meiry Sayuri Tsuda Marcos Toshiyuki Tanita Ivanil Aparecida Moro Kauss Josiane Festti Cláudia Maria Dantas de Maio Carrilho Cintia Magalhães Carvalho Grion Lucienne Tibery Queiroz Cardoso 10.6084/m9.figshare.6235133.v1 https://scielo.figshare.com/articles/dataset/Acute_kidney_injury_and_intra-abdominal_hypertension_in_burn_patients_in_intensive_care/6235133 <p></p><p>ABSTRACT Objective: To evaluate the frequency of intra-abdominal hypertension in major burn patients and its association with the occurrence of acute kidney injury. Methods: This was a prospective cohort study of a population of burn patients hospitalized in a specialized intensive care unit. A convenience sample was taken of adult patients hospitalized in the period from 1 August 2015 to 31 October 2016. Clinical and burn data were collected, and serial intra-abdominal pressure measurements taken. The significance level used was 5%. Results: A total of 46 patients were analyzed. Of these, 38 patients developed intra-abdominal hypertension (82.6%). The median increase in intra-abdominal pressure was 15.0mmHg (interquartile range: 12.0 to 19.0). Thirty-two patients (69.9%) developed acute kidney injury. The median time to development of acute kidney injury was 3 days (interquartile range: 1 - 7). The individual analysis of risk factors for acute kidney injury indicated an association with intra-abdominal hypertension (p = 0.041), use of glycopeptides (p = 0.001), use of vasopressors (p = 0.001) and use of mechanical ventilation (p = 0.006). Acute kidney injury was demonstrated to have an association with increased 30-day mortality (log-rank, p = 0.009). Conclusion: Intra-abdominal hypertension occurred in most patients, predominantly in grades I and II. The identified risk factors for the occurrence of acute kidney injury were intra-abdominal hypertension and use of glycopeptides, vasopressors and mechanical ventilation. Acute kidney injury was associated with increased 30-day mortality.</p><p></p> 2018-05-09 05:44:50 Intensive care units Renal insufficiency Intra-abdominal hypertension Burn units Burns Multiple organ failure