%0 Generic %A Talizin, Thalita Bento %A Tsuda, Meiry Sayuri %A Tanita, Marcos Toshiyuki %A Kauss, Ivanil Aparecida Moro %A Festti, Josiane %A Carrilho, Cláudia Maria Dantas de Maio %A Grion, Cintia Magalhães Carvalho %A Cardoso, Lucienne Tibery Queiroz %D 2018 %T Acute kidney injury and intra-abdominal hypertension in burn patients in intensive care %U https://scielo.figshare.com/articles/dataset/Acute_kidney_injury_and_intra-abdominal_hypertension_in_burn_patients_in_intensive_care/6235133 %R 10.6084/m9.figshare.6235133.v1 %2 https://scielo.figshare.com/ndownloader/files/11384243 %2 https://scielo.figshare.com/ndownloader/files/11384246 %2 https://scielo.figshare.com/ndownloader/files/11384249 %2 https://scielo.figshare.com/ndownloader/files/11384252 %2 https://scielo.figshare.com/ndownloader/files/11384255 %K Intensive care units %K Renal insufficiency %K Intra-abdominal hypertension %K Burn units %K Burns %K Multiple organ failure %X

ABSTRACT Objective: To evaluate the frequency of intra-abdominal hypertension in major burn patients and its association with the occurrence of acute kidney injury. Methods: This was a prospective cohort study of a population of burn patients hospitalized in a specialized intensive care unit. A convenience sample was taken of adult patients hospitalized in the period from 1 August 2015 to 31 October 2016. Clinical and burn data were collected, and serial intra-abdominal pressure measurements taken. The significance level used was 5%. Results: A total of 46 patients were analyzed. Of these, 38 patients developed intra-abdominal hypertension (82.6%). The median increase in intra-abdominal pressure was 15.0mmHg (interquartile range: 12.0 to 19.0). Thirty-two patients (69.9%) developed acute kidney injury. The median time to development of acute kidney injury was 3 days (interquartile range: 1 - 7). The individual analysis of risk factors for acute kidney injury indicated an association with intra-abdominal hypertension (p = 0.041), use of glycopeptides (p = 0.001), use of vasopressors (p = 0.001) and use of mechanical ventilation (p = 0.006). Acute kidney injury was demonstrated to have an association with increased 30-day mortality (log-rank, p = 0.009). Conclusion: Intra-abdominal hypertension occurred in most patients, predominantly in grades I and II. The identified risk factors for the occurrence of acute kidney injury were intra-abdominal hypertension and use of glycopeptides, vasopressors and mechanical ventilation. Acute kidney injury was associated with increased 30-day mortality.

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