10.6084/m9.figshare.6944201.v1
Gabriel Keine Kuga
Gabriel Keine
Kuga
Rafael Calais Gaspar
Rafael Calais
Gaspar
Vitor Rosetto Muñoz
Vitor Rosetto
Muñoz
Susana Castelo Branco Ramos Nakandakari
Susana Castelo Branco Ramos
Nakandakari
Leonardo Breda
Leonardo
Breda
Bruna Marina Sandoval
Bruna Marina
Sandoval
Flávio Henrique Caetano
Flávio Henrique
Caetano
José Alexandre Curiacos de Almeida Leme
José Alexandre Curiacos de Almeida
Leme
José Rodrigo Pauli
José Rodrigo
Pauli
Ricardo José Gomes
Ricardo José
Gomes
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats
SciELO journals
2018
Diabetes mellitus
Exercise
Liver
Wistar, rats
2018-08-08 02:50:55
Dataset
https://scielo.figshare.com/articles/dataset/Physical_training_reverses_changes_in_hepatic_mitochondrial_diameter_of_Alloxan-induced_diabetic_rats/6944201
<div><p>ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks. At the end of the experiment, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, albumin and total protein. Liver samples were extracted for measurements of glycogen, protein, DNA and mitochondrial diameter determination. Results The sedentary diabetic animals presented decreased body weight, blood insulin, and hepatic glycogen, as well as increased glycemia and mitochondrial diameter. The physical training protocol in diabetic animals was efficient to recovery body weight and liver glycogen, and to decrease the hepatic mitochondrial diameter. Conclusion Physical training ameliorated hepatic metabolism and promoted important morphologic adaptations as mitochondrial diameter in liver of the diabetic rats.</p></div>