%0 Generic %A Gabriel, Heloisa B %A Azevedo, Mauro F %A Kimura, Emília A %A Katzin, Alejandro M %D 2018 %T Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate %U https://scielo.figshare.com/articles/dataset/Plasmodium_falciparum_parasites_overexpressing_farnesyl_diphosphate_synthase_geranylgeranyl_diphosphate_synthase_are_more_resistant_to_risedronate/6967661 %R 10.6084/m9.figshare.6967661.v1 %2 https://scielo.figshare.com/ndownloader/files/12779615 %2 https://scielo.figshare.com/ndownloader/files/12779618 %K P. falciparum %K FPPS/GGPPS %K risedronate %K overexpression %X

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.

%I SciELO journals