10.6084/m9.figshare.6992774.v1
Erica de Souza Fernandes
Erica de Souza
Fernandes
Virgínia Maria de Barros Lorena
Virgínia Maria de Barros
Lorena
Iana Rafaela Fernandes Sales
Iana Rafaela Fernandes
Sales
Mônica Camelo Pessoa de Azevedo Albuquerque
Mônica Camelo Pessoa de Azevedo
Albuquerque
Yara de Miranda Gomes
Yara
de Miranda Gomes
Vlaudia Maria Assis Costa
Vlaudia Maria Assis
Costa
Valdênia Maria Oliveira de Souza
Valdênia Maria Oliveira de
Souza
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
SciELO journals
2018
Maternal schistosomiasis
Adult offspring
Immunomodulation
2018-08-22 02:58:18
Dataset
https://scielo.figshare.com/articles/dataset/Maternal_schistosomiasis_IL-2_IL-10_and_regulatory_T_lymphocytes_to_unrelated_antigen_in_adult_offspring_mice/6992774
<div><p>Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.</p></div>