Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Erica de Souza Fernandes
Virgínia Maria de Barros Lorena
Iana Rafaela Fernandes Sales
Mônica Camelo Pessoa de Azevedo Albuquerque
Yara de Miranda Gomes
Vlaudia Maria Assis Costa
Valdênia Maria Oliveira de Souza
10.6084/m9.figshare.6992774.v1
https://scielo.figshare.com/articles/dataset/Maternal_schistosomiasis_IL-2_IL-10_and_regulatory_T_lymphocytes_to_unrelated_antigen_in_adult_offspring_mice/6992774
<div><p>Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.</p></div>
2018-08-22 02:58:18
Maternal schistosomiasis
Adult offspring
Immunomodulation