Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice Erica de Souza Fernandes Virgínia Maria de Barros Lorena Iana Rafaela Fernandes Sales Mônica Camelo Pessoa de Azevedo Albuquerque Yara de Miranda Gomes Vlaudia Maria Assis Costa Valdênia Maria Oliveira de Souza 10.6084/m9.figshare.6992774.v1 https://scielo.figshare.com/articles/dataset/Maternal_schistosomiasis_IL-2_IL-10_and_regulatory_T_lymphocytes_to_unrelated_antigen_in_adult_offspring_mice/6992774 <div><p>Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.</p></div> 2018-08-22 02:58:18 Maternal schistosomiasis Adult offspring Immunomodulation