%0 Generic %A Fernandes, Erica de Souza %A Lorena, Virgínia Maria de Barros %A Sales, Iana Rafaela Fernandes %A Albuquerque, Mônica Camelo Pessoa de Azevedo %A de Miranda Gomes, Yara %A Costa, Vlaudia Maria Assis %A Souza, Valdênia Maria Oliveira de %D 2018 %T Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice %U https://scielo.figshare.com/articles/dataset/Maternal_schistosomiasis_IL-2_IL-10_and_regulatory_T_lymphocytes_to_unrelated_antigen_in_adult_offspring_mice/6992774 %R 10.6084/m9.figshare.6992774.v1 %2 https://scielo.figshare.com/ndownloader/files/12831911 %2 https://scielo.figshare.com/ndownloader/files/12831914 %K Maternal schistosomiasis %K Adult offspring %K Immunomodulation %X

Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.

%I SciELO journals