Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy Yrbani Lantigua-Dorville Maria Antonia Saornil Ciro García-Alvarez Elena García-Lagarto 10.6084/m9.figshare.7101332.v1 https://scielo.figshare.com/articles/dataset/Choroidal_melanoma_recurrence_after_episcleral_brachytherapy_and_transpupillary_thermotherapy/7101332 <div><p>ABSTRACT A 68-year-old man diagnosed with choroidal melanoma (CM) in the right eye underwent treatment with episcleral brachytherapy (I125) and transpupillary thermotherapy. Ultrasound, computed tomography, and magnetic resonance imaging were performed and revealed ocular recurrence of CM. Treatment with extended enucleation was performed. Macroscopic and microscopic examinations revealed extraocular extension and malignant cells, respectively. Immunohistochemistry demonstrated tumoral Melan-A and HMB-45 expression. No cytogenic abnormalities were detected with fluorescence in situhybridization of tumor cells using probes against chromosomes 3q27 and 8q24. The patient underwent adjuvant external beam radiotherapy for treatment of residual tumor tissue. This case represents the first reported case of recurrent CM with no cytogenetic abnormalities and the absence of metastatic disease, despite a number of the poorest prognostic factors.</p></div> 2018-09-19 02:46:31 Choroid neoplasms Melanoma Neoplasm recurrence, local Brachytherapy Case reports