%0 Generic %A Vargas, Diva %A Castro, Cleudson %D 2018 %T Pupillometry in Chagas disease %U https://scielo.figshare.com/articles/dataset/Pupillometry_in_Chagas_disease/7102136 %R 10.6084/m9.figshare.7102136.v1 %2 https://scielo.figshare.com/ndownloader/files/13070171 %2 https://scielo.figshare.com/ndownloader/files/13070183 %2 https://scielo.figshare.com/ndownloader/files/13070186 %2 https://scielo.figshare.com/ndownloader/files/13070189 %2 https://scielo.figshare.com/ndownloader/files/13070192 %2 https://scielo.figshare.com/ndownloader/files/13070198 %2 https://scielo.figshare.com/ndownloader/files/13070204 %K Pupil physiology %K Parasymphatetic denervation %K Hypersensitivity %K Intraocular pressure %K Pilocarpine %K Chagas disease %X

ABSTRACT Purpose: We investigated parasympathetic innervation abnormalities of the iris sphincter and ciliary muscles in chronic Chagas disease by measuring pupillary diameter and intraocular pressure. Methods: A group of 80 patients with Chagas disease was compared with 76 healthy individuals without chagasic infection. The following procedures were performed: pupillometry, hypersensitivity test to pilocarpine 0.125%, intraocular pressure measurement (IOP), basal pupil diameter (BPD), absolute pupillary constriction amplitude (ACA), relative pupillary constriction amplitude (RCA) and the presence of anisocoria. Results: The prevalence of anisocoria was higher in chagasic patients (p<0.01). These patients had mean basal pupillary diameter, mean photopic pupillary diameter and mean value of absolute pupillary constriction amplitude significantly lower than non-chagasic ones (p<0.01, mean difference -0.50mm), (p=0.02, mean difference -0.20mm), (p<0.01, mean difference -0.29mm), respectively. The relative pupillary constriction amplitude did not differ between the two groups (p=0.39, mean difference -1.15%). There was hypersensitivity to dilute pilocarpine in 8 (10%) of the chagasic patients in the right eye and in 2 (2.5%) in the left eye and in 1 (1.25%) in both eyes. The mean value of intraocular pressure had a marginal statistical significance between the two groups (p=0.06, mean difference -0.91mmHg). Conclusions: Patients with chagasic infection may exhibit ocular parasympathetic dysfunction, demonstrable by pupillometry and the dilute pilocarpine hypersensitivity test.

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