10.6084/m9.figshare.7185980.v1 Samy B. Said Samy B. Said Fawzia Z. El-Ablack Fawzia Z. El-Ablack Hani M. Elbeheiry Hani M. Elbeheiry Synthesis and Characterization of Newly Fused 1,2-Dihydropyrido[3,4-b], Bridged Oxadiazol-2-yl, 4-Substituted-benzylidene Hydrazide and Arylidene 6-Chloroquinoxaline 1,4-Dioxides SciELO journals 2018 quinoxaline 1,4-dioxide transamination enamine arylidene hydrazide 2018-10-10 02:48:49 Dataset https://scielo.figshare.com/articles/dataset/Synthesis_and_Characterization_of_Newly_Fused_1_2-Dihydropyrido_3_4-b_Bridged_Oxadiazol-2-yl_4-Substituted-benzylidene_Hydrazide_and_Arylidene_6-Chloroquinoxaline_1_4-Dioxides/7185980 <div><p>Some simple reactions using commercially available chemicals were used in the preparation of new biologically remarkable quinoxaline 1,4-dioxide derivatives. Several steps performed on 4-chloro-2-nitroaniline resulted in a quinoxaline 1,4-dioxide derivative, which reacted with dimethylformamide dimethylacetal (DMF-DMA) to produce an enamine. Transamination of this enamine with anilines gave the fused 1,2-dihydropyrido[3,4-b]quinoxaline 5,10-dioxide derivatives via an addition-elimination mechanism. Basic condensation reaction of quinoxaline active methyl afforded unexpected decarboxylated arylidene derivatives by using different aromatic aldehydes. Bridged oxadiazol-2-yl derivatives were obtained from the reaction of a hydrazide derivative with carbon disulfide and p-nitrobenzoic acid respectively. Whereas, acidic condensation of that hydrazide with aromatic aldehydes afforded the arylidene hydrazides.</p></div>