Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits OliveiraFlávio Augusto de Souza PassariniGuilherme Matos MedeirosDaniel Sol Sol de SantosAna Paula de Azevedo FialhoSaara Neri GouveiaAurileya de Jesus LatorreMarcinete FreitagElci Marlei MedeirosPatrícia Soares de Maria de TelesCarolina Bioni Garcia FacundoValdir Alves 2018 <div><p> Abstract INTRODUCTION This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. METHODS The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. RESULTS Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. CONCLUSIONS The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.</p></div>