10.6084/m9.figshare.7452785.v1
Kamila Rangel Primo FERNANDES
Kamila Rangel Primo
FERNANDES
Paulo Senna BITTERCOURT
Paulo Senna
BITTERCOURT
Afonso Duarte Leão de SOUZA
Afonso Duarte Leão de
SOUZA
Antonia Queiroz Lima de SOUZA
Antonia Queiroz Lima de
SOUZA
Felipe Moura Araújo da SILVA
Felipe Moura Araújo da
SILVA
Emerson Silva LIMA
Emerson Silva
LIMA
Leonard Domingo Rosales ACHO
Leonard Domingo Rosales
ACHO
Rita de Cássia Saraiva NUNOMURA
Rita de Cássia Saraiva
NUNOMURA
Ana Frazão TEIXEIRA
Ana Frazão
TEIXEIRA
Hector Henrique Ferreira KOOLEN
Hector Henrique Ferreira
KOOLEN
Phenolic compounds from Virola venosa (Myristicaceae) and evaluation of their antioxidant and enzyme inhibition potential
SciELO journals
2018
α-glucosidase inhibition
antioxidant compounds
ferulic acid
Amazon
2018-12-12 03:16:00
Dataset
https://scielo.figshare.com/articles/dataset/Phenolic_compounds_from_Virola_venosa_Myristicaceae_and_evaluation_of_their_antioxidant_and_enzyme_inhibition_potential/7452785
<div><p>ABSTRACT Virola venosa, popularly known in Brazil as ucuuba-da-mata, occurs naturally in the Amazon region and has potential to provide useful natural compounds, as already known for other Virola species. Therefore, the objective of this study was to determine the chemical composition of bark and leaf extracts of V. venosa, and to test the antioxidant capacity and α-glucosidase inhibition potential of their compounds. Polar extracts showed to be more active in both assays, therefore a bioactivity-guided fractionation was performed to identify the compounds that were responsible for the recorded activities. Using a combination of LC-MS/MS analysis and isolation with NMR identification, eight phenolic compounds were identified. Assays with pure compounds of the active fraction revealed that ferulic acid was the main contributor compound to the observed bioactivity in the crude extracts.</p></div>