10.6084/m9.figshare.7482626.v1 J Xiong J Xiong H Qiu H Qiu Y Bi Y Bi HL Zhou HL Zhou S Guo S Guo B Ding B Ding Effects of Dietary Supplementation with Tributyrin and Coated Sodium Butyrate on Intestinal Morphology, Disaccharidase Activity and Intramuscular Fat of Lipopolysaccharide-Challenged Broilers SciELO journals 2018 Broilers coated sodium butyrate intestine lipopolysaccharide tributyrin 2018-12-19 03:16:23 Dataset https://scielo.figshare.com/articles/dataset/Effects_of_Dietary_Supplementation_with_Tributyrin_and_Coated_Sodium_Butyrate_on_Intestinal_Morphology_Disaccharidase_Activity_and_Intramuscular_Fat_of_Lipopolysaccharide-Challenged_Broilers/7482626 <div><p>ABSTRACT The objectives of this study were to investigate the effects of tributyrin (TB) and coated sodium butyrate (CSB) on intestinal morphology, disaccharidase activity and intramuscular fat of broilers challenged with lipopolysaccharide (LPS). A total of 160 1-day-old healthy Cobb broilers were randomly allocated into four groups: (1) control; (2) LPS, in which broilers were fed a basal diet and intraperitoneally injected with 500 μg/kg LPS on days 38, 40 and 42; (3) TB, in which LPS-challenged broilers were fed basal diet supplemented with 500 mg/kg TB; and (4) CSB, in which LPS-challenged broilers were fed basal diet supplemented with 877 mg/kg CSB. Addition of TB and CSB inhibited (p<0.05) the decrease in villus height in the duodenum and ileum of LPS-challenged broilers, respectively. Both TB and CSB increased (p<0.05) activity of maltase in the small intestine, and TB increased (p<0.05) activity of isomaltase in the ileum. Additionally, dietary addition of TB and CSB decreased (p<0.05) the content of intramuscular fat. In conclusion, dietary supplementation of TB was more effective than CSB in improving intestinal morphology and disaccharidase activity of LPS-challenged broilers, and they both reduced intramuscular fat in the breast and legs.</p></div>