%0 Generic %A Rosário, Pedro Weslley %A Batista, Kelly Cristina Siqueira %A Calsolari, Maria Regina %D 2018 %T Radioiodine-induced oxidative stress in patients with differentiated thyroid carcinoma and effect of supplementation with vitamins C and E and selenium (antioxidants) %U https://scielo.figshare.com/articles/dataset/Radioiodine-induced_oxidative_stress_in_patients_with_differentiated_thyroid_carcinoma_and_effect_of_supplementation_with_vitamins_C_and_E_and_selenium_antioxidants_/7517489 %R 10.6084/m9.figshare.7517489.v1 %2 https://scielo.figshare.com/ndownloader/files/13973048 %2 https://scielo.figshare.com/ndownloader/files/13973054 %2 https://scielo.figshare.com/ndownloader/files/13973060 %K Thyroid cancer %K radioiodine %K oxidative stress %K antioxidant %X

ABSTRACT Objective The objective of this study, in addition to confirming that therapy with 131I causes oxidative stress, was to evaluate the effect of supplementation with vitamins C and E and selenium on this phenomenon by measuring plasma 8-epi-PGF2a, a marker of lipid peroxidation. Subjects and methods Forty patients with thyroid cancer submitted to thyroidectomy, who received 3.7 GBq 131I after levothyroxine withdrawal, were selected; 20 patients did not receive (control group) and 20 patients received (intervention group) daily supplementation consisting of 2000 mg vitamin C, 1000 mg vitamin E and 400 µg selenium for 21 days before 131I. Plasma 8-epi-PGF2a was measured immediately before and 2 and 7 days after 131I. Results A significant increase in plasma 8-epi-PGF2a after 131I was observed in the two groups. The concentrations of 8-epi-PGF2α were significantly higher in the control group before and 2 and 7 days after 131I. The percentage of patients with elevated 8-epi-PGF2α was also significantly higher in the control group before and after 131I. Furthermore, the increase (percent) in 8-epi-PGF2α was significantly greater in the control group (average of 112.3% versus 56.3%). Only two patients (10%) reported side effects during supplementation. Conclusions Ablation with 131I causes oxidative stress which can be minimized by the use of antioxidants.

%I SciELO journals