10.6084/m9.figshare.7562615.v1 Leandro Teixeira de Castro Leandro Teixeira de Castro Itamar de Souza Santos Itamar de Souza Santos Alessandra C. Goulart Alessandra C. Goulart Alexandre da Costa Pereira Alexandre da Costa Pereira Henrique Lane Staniak Henrique Lane Staniak Marcio Sommer Bittencourt Marcio Sommer Bittencourt Paulo Andrade Lotufo Paulo Andrade Lotufo Isabela Martins Bensenor Isabela Martins Bensenor Elevated High-Sensitivity Troponin I in the Stabilized Phase after an Acute Coronary Syndrome Predicts All-Cause and Cardiovascular Mortality in a Highly Admixed Population: A 7-Year Cohort SciELO journals 2019 Coronary Artery Disease / mortality Troponin I Prognosis Metabolic Syndrome Biological Variation, Population Risk Factors 2019-01-09 02:44:56 Dataset https://scielo.figshare.com/articles/dataset/Elevated_High-Sensitivity_Troponin_I_in_the_Stabilized_Phase_after_an_Acute_Coronary_Syndrome_Predicts_All-Cause_and_Cardiovascular_Mortality_in_a_Highly_Admixed_Population_A_7-Year_Cohort/7562615 <div><p>Abstract Background: High-sensitivity cardiac troponin I (hs-cTnI) has played an important role in the risk stratification of patients during the in-hospital phase of acute coronary syndrome (ACS), but few studies have determined its role as a long-term prognostic marker in the outpatient setting. Objective: To investigate the association between levels of hs-cTnI measured in the subacute phase after an ACS event and long-term prognosis in a highly admixed population. Methods: We measured levels of hs-cTnI in 525 patients 25 to 90 days after admission for an ACS event; these patients were then divided into tertiles according to hs-cTnI levels and followed for up to 7 years. We compared all-cause and cardiovascular mortality using Cox proportional hazards models and adopting a significance level of 5%. Results: After a median follow-up of 51 months, patients in the highest tertile had a greater hazard ratio (HR) for all-cause mortality after adjustment for age, sex, known cardiovascular risk factors, medication use, and demographic factors (HR: 3.84, 95% CI: 1.92-8.12). These findings persisted after further adjustment for estimated glomerular filtration rate < 60 ml/min/1.73 m2 and left ventricular ejection fraction < 0.40 (HR: 6.53, 95% CI: 2.12-20.14). Cardiovascular mortality was significantly higher in the highest tertile after adjustment for age and sex (HR: 5.65, 95% CI: 1.94-16.47) and both in the first (HR: 4.90, 95% CI: 1.35-17.82) and second models of multivariate adjustment (HR: 5.89, 95% CI: 1.08-32.27). Conclusions: Elevated hs-cTnI levels measured in the stabilized phase after an ACS event are independent predictors of all-cause and cardiovascular mortality in a highly admixed population.</p></div>