10.6084/m9.figshare.7743128.v1
Francisco Heine Ferreira Machado
Francisco Heine Ferreira
Machado
Heladio Feitosa de Castro Filho
Heladio Feitosa de
Castro Filho
Rodrigo Feitosa de Albuquerque Lima Babadopulos
Rodrigo Feitosa de Albuquerque Lima
Babadopulos
Hermano Alexandre Lima Rocha
Hermano Alexandre Lima
Rocha
José Lima de Carvalho Rocha
José Lima de Carvalho
Rocha
Manoel Odorico de Moraes Filho
Manoel
Odorico de Moraes Filho
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
SciELO journals
2019
Obesity
Bariatric Surgery
Gallstones
Ursodeoxycholic Acid
2019-02-20 02:40:51
Dataset
https://scielo.figshare.com/articles/dataset/Ursodeoxycholic_acid_in_the_prevention_of_gallstones_in_patients_subjected_to_Roux-en-Y_gastric_bypass/7743128
<div><p>Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.</p></div>