%0 Generic %A Alves, Geisa Cristina da Silva %A Chequer, Farah Maria Drumond %A Sanches, Cristina %D 2019 %T Effective vancomycin concentrations in children: a cross-sectional study %U https://scielo.figshare.com/articles/dataset/Effective_vancomycin_concentrations_in_children_a_cross-sectional_study/7743521 %R 10.6084/m9.figshare.7743521.v1 %2 https://scielo.figshare.com/ndownloader/files/14408552 %2 https://scielo.figshare.com/ndownloader/files/35774298 %2 https://scielo.figshare.com/ndownloader/files/35774301 %2 https://scielo.figshare.com/ndownloader/files/35774304 %2 https://scielo.figshare.com/ndownloader/files/35774307 %2 https://scielo.figshare.com/ndownloader/files/35774310 %2 https://scielo.figshare.com/ndownloader/files/35774313 %2 https://scielo.figshare.com/ndownloader/files/35774316 %K Microbial sensitivity tests %K Pharmacokinetics %K Pharmacologic actions %K Vancomycin %K Child %X

ABSTRACT Objective Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. Methods This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour interval between each withdrawal. Results Ten pediatric patients with median age of 5.5 years and interquartile range (IQR) of 3.2-9.0 years, median weight of 21kg (IQR: 15.5-24.0kg) and median height of 112.5cm (IQR: 95-133cm), were included. Only one child achieved trough concentrations between 10µg/mL and 15µg/mL. Conclusion The empirical use of vancomycin in the children studied did not achieve the therapeutic pharmacokinetic/pharmacodynamic target for minimum inhibitory concentration of 1µg/mL.

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