Nunes, Renata Portella Hirai, Flávio Eduardo Barroso, Letícia Fernandes Badaró, Emmerson Novais, Eduardo Rodrigues, Eduardo Buchele Maia, Mauricio Magalhães Jr., Octaviano Eid Farah, Michel Effectiveness of monthly and fortnightly anti-VEGF treatments for age-related macular degeneration <div><p>ABSTRACT Purpose: To study the efficacy and safety of treatments with ranibizumab and bevacizumab for exudative age-related macular degeneration. Methods: A parallel randomized clinical trial was conducted to compare the efficacy and safety of three regimens (bevacizumab every month, bevacizumab every 2 weeks, and ranibizumab every month), followed by as-needed retreatments, for 1 year, in previously untreated individuals with age-related macular degeneration. The primary outcome was change in visual acuity and in central macular thickness after 1 year of follow-up. Subjects were assigned randomly to one of the three groups in a 1:1:1 ratio, and investigators and examiners were blinded to the randomization results. Results: We included 15 patients in each group. After 1 year of follow-up, we found statistically significant improvements in visual acuity and central macular thickness reduction in all groups. However, we found no statistically significant differences between the three groups. Conclusions: The bi-weekly follow-up was effective and we found no significant differences in efficacy or safety between the treatments with ranibizumab and bevacizumab.</p></div> Macular degeneration;Retina;Bevacizumab;Ranibizumab;Clinical trial 2019-02-27
    https://scielo.figshare.com/articles/dataset/Effectiveness_of_monthly_and_fortnightly_anti-VEGF_treatments_for_age-related_macular_degeneration/7773458
10.6084/m9.figshare.7773458.v1