%0 Generic %A Zamyad, Mahnaz %A Abbasnejad, Mehdi %A Esmaeili-Mahani, Saeed %A Mostafavi, Ali %A Sheibani, Vahid %D 2019 %T The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats %U https://scielo.figshare.com/articles/dataset/The_anticonvulsant_effects_of_Ducrosia_anethifolia_Boiss_essential_oil_are_produced_by_its_main_component_alpha-pinene_in_rats/7773599 %R 10.6084/m9.figshare.7773599.v1 %2 https://scielo.figshare.com/ndownloader/files/14474018 %2 https://scielo.figshare.com/ndownloader/files/14474021 %2 https://scielo.figshare.com/ndownloader/files/14474027 %2 https://scielo.figshare.com/ndownloader/files/14474033 %2 https://scielo.figshare.com/ndownloader/files/14474039 %2 https://scielo.figshare.com/ndownloader/files/14474045 %2 https://scielo.figshare.com/ndownloader/files/14474054 %2 https://scielo.figshare.com/ndownloader/files/14474063 %K Pentytenetetrazote %K seizures %K oxidative stress %X

ABSTRACT Ducrosia anethifolia has been recommended as a remedy for neurological disorders. However, the anticonvulsant effects of D. anethifolia essential oil (DAEO) and its major constituent α-pinene have not yet been clarified. Methods: A rat model of pentylenetetrazole (PTZ)-induced convulsions was used. Oxidant and antioxidant parameters were assayed in the temporal lobe. Results: The data showed that DAEO (50, 100 and 200 mg/kg, i.p.) and α-pinene (0.2 and 0.4 mg/kg i.p.) delayed the initiation time, and reduced the duration of myoclonic and tonic-clonic seizures following PTZ injection. The PTZ produced oxidative stress so that malondialdehyde and hydrogen peroxide levels were increased and catalase and peroxidase activity decreased. Pretreatment with DAEO and α-pinene significantly inhibited the above-mentioned enzymatic changes in PTZ-treated animals. Conclusion: The results suggest that α-pinene, at teast in part, was responsible for the induction of the anticonvulsant and antioxidant effects of DAEO in rats.

%I SciELO journals