10.6084/m9.figshare.7806659.v1 Guangming Zhang Guangming Zhang Guanghua Cui Guanghua Cui Shuangxi Tong Shuangxi Tong Qingxian Cao Qingxian Cao Salvianolic acid A alleviates the renal damage in rats with chronic renal failure SciELO journals 2019 Salvianolic acid A Kidney Failure, Chronic Oxidative Stress Bone Morphogenetic Protein 7 Smad6 Protein Rats 2019-03-06 02:40:22 Dataset https://scielo.figshare.com/articles/dataset/Salvianolic_acid_A_alleviates_the_renal_damage_in_rats_with_chronic_renal_failure/7806659 <div><p>Abstract Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF). Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. The rats in group CRF+SAA were intragastrically administrated with 10 mg/kg SAA for 8 weeks. The blood urine nitrogen (BUN), urine creatinine (Ucr), creatinine clearance rate (Ccr), and serum uperoxide dismutase (SOD) and malondialdehyde (MDA) were tested. The expressions of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 7 (BMP-7) and Smad6 protein in renal tissue were determined. Results: After treatment, compared with group CRF, in group CRF+SAA the BUN, Scr, serum MDA and kidney/body weight ratio were decreased, the Ccr and serum SOD were increased, the TGF-β1 protein expression level in renal tissue was decreased, and the BMP-7 and Smad6 protein levels were increased (all P < 0.05). Conclusion: SAA can alleviate the renal damage in CRF rats through anti-oxidant stress, down-regulation of TGF-β1 signaling pathway and up-regulation of BMP-7/Smad6 signaling pathway.</p></div>