10.6084/m9.figshare.7865993.v1 Gabriel Pacífico Seabra Nunes Gabriel Pacífico Seabra Nunes Patrícia da Silva Cunha Patrícia da Silva Cunha Daniele Patrícia Dal Bosco Daniele Patrícia Dal Bosco Sandra Lúcia Euzébio Ribeiro Sandra Lúcia Euzébio Ribeiro Challenging Management of Hepatitis B infection in Ankylosing Spondylitis Patients in an Endemic Area during Immunosuppressive Therapy SciELO journals 2019 Hepatitis Reactivation Immunosuppressive therapy Ankylosing spondylitis 2019-03-20 02:48:40 Figure https://scielo.figshare.com/articles/figure/Challenging_Management_of_Hepatitis_B_infection_in_Ankylosing_Spondylitis_Patients_in_an_Endemic_Area_during_Immunosuppressive_Therapy/7865993 <div><p>Abstract Hepatitis B infection is a global health issue. When considering patients with rheumatic diseases, this is no different. By using immunosuppressant drugs, such as DMARDs and biologics, viral reactivation is possible, leading to serious consequences on the patient. We report 3 cases of association between ankylosing spondylitis and hepatitis B with the use of immunosuppressant drugs. Case 1 was a patient with previous HBV infection using DMARD. Cases 2 and 3 were patients chronically infected by HBV during immunosuppressant therapy. The management of HBV infection during immunosuppressant therapy is challenging and needs multidisciplinary support.</p></div>