%0 Generic %A Li, Yi-Lin %A Zhang, Shuo %A Guo, Xiao-Peng %A Gao, Lu %A Lian, Wei %A Yao, Yong %A Deng, Kan %A Wang, Ren-Zhi %A Xing, Bing %D 2019 %T Correlation analysis between short-term insulin-like growth factor-I and glucose intolerance status after transsphenoidal adenomectomy in acromegalic patients: a large retrospective study from a single center in China %U https://scielo.figshare.com/articles/dataset/Correlation_analysis_between_short-term_insulin-like_growth_factor-I_and_glucose_intolerance_status_after_transsphenoidal_adenomectomy_in_acromegalic_patients_a_large_retrospective_study_from_a_single_center_in_China/7898483 %R 10.6084/m9.figshare.7898483.v1 %2 https://scielo.figshare.com/ndownloader/files/14708522 %2 https://scielo.figshare.com/ndownloader/files/14708528 %2 https://scielo.figshare.com/ndownloader/files/14708531 %2 https://scielo.figshare.com/ndownloader/files/14708537 %2 https://scielo.figshare.com/ndownloader/files/14708540 %2 https://scielo.figshare.com/ndownloader/files/14708543 %K Glucose tolerance %K diabetes %K acromegaly %K transsphenoidal surgery %K insulin-like growth factor-I %X

ABSTRACT Objectives: Our study aimed to investigate the associations of glucose tolerance status with insulin-like growth factor-I (IGF-I) and other clinical laboratory parameters of acromegalic patients before and after the patients underwent transsphenoidal adenomectomy (TSA) by conducting a single-center, retrospective study. Subjects and methods: A total of 218 patients with acromegaly who had undergone TSA as the first treatment were retrospectively analyzed. Serum IGF-I, growth hormone (GH) and glucose levels were measured before and after surgery. Results: The follow-up levels for random GH, GH nadir, and the percentage of the upper limit of normal IGF-I (%ULN IGF-I) were decreased significantly. The percentages of normal (39.0%), early carbohydrate metabolism disorders (33.0%) and diabetes mellitus (28.0%) changed to 70.2%, 16.5% and 13.3%, respectively, after TSA. %ULN IGF-I at baseline was higher in the diabetes mellitus (DM) group than in the normal glucose tolerance group and impaired glucose tolerance (IGT) /impaired fasting glucose (IFG) groups before TSA, and the DM group exhibited a greater reduction in %ULN IGF-I value after surgery. The follow-up %ULN IGF-I value after surgery was significantly lower in the improved group, and Pearson's correlation analysis revealed that the reductions in %ULN IGF-I corresponded with the reductions in glucose level. Conclusion: This study examined the largest reported sample with complete preoperative and follow-up data. The results suggest that the age- and sex-adjusted IGF-I level, which reflects altered glucose metabolism, and the change of it are associated with improved glucose tolerance in acromegalic patients both before and after TSA.

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