10.6084/m9.figshare.7974095.v1 Aline R. Fernandes Aline R. Fernandes Ricardo A. Bernardo Ricardo A. Bernardo Thays C. de Carvalho Thays C. de Carvalho Boniek G. Vaz Boniek G. Vaz Andréa R. Chaves Andréa R. Chaves Graphene Oxides Coated Paper as a Substrate to Paper Spray Ionization Mass Spectrometry for Creatinine Determination in Urine Samples SciELO journals 2019 paper spray ionization graphene oxide creatinine urine mass spectrometry 2019-04-10 02:42:21 Dataset https://scielo.figshare.com/articles/dataset/Graphene_Oxides_Coated_Paper_as_a_Substrate_to_Paper_Spray_Ionization_Mass_Spectrometry_for_Creatinine_Determination_in_Urine_Samples/7974095 <div><p>Paper spray ionization (PSI) is a promising analytical tool for direct analysis in mass spectrometry (MS). However, this technique usually uses chromatographic paper, which rarely accomplishes a stable MS signal and could vary with the sample matrix effect. In the present study, the application of graphene oxides (GO) was scrutinized as modifier paper substrate for PSI-MS methods. The developed substrate efficiency was evaluated towards creatinine determination in urine samples. The GO-PSI-MS developed method for creatinine in urine samples showed linearity in the range of 0.1 to 3.4 ppm with R2 = 0.9991. The precision was evaluated and the values were between 1.1 to 6.8% and the accuracy above 96.8%. The limit of quantification (LOQ) and limit of detection (LOD) were 0.05 and 0.17 ppm, respectively. The GO-PSI developed was compared to conventional chromatographic paper for PSI-MS methods, and the results showed that the modified paper with GO bolsters method linearity, precision, and LOQ values.</p></div>