10.6084/m9.figshare.7974428.v1
Guilherme Wesley Peixoto da Fonseca
Guilherme Wesley Peixoto da
Fonseca
Marcelo Rodrigues dos Santos
Marcelo Rodrigues dos
Santos
Francis Ribeiro de Souza
Francis Ribeiro de
Souza
Marcel Jose A. da Costa
Marcel Jose A. da
Costa
Stephan von Haehling
Stephan
von Haehling
Liliam Takayama
Liliam
Takayama
Rosa Maria R. Pereira
Rosa
Maria R. Pereira
Carlos Eduardo Negrão
Carlos
Eduardo Negrão
Stefan D. Anker
Stefan
D. Anker
Maria Janieire de Nazaré Nunes Alves
Maria Janieire de Nazaré Nunes
Alves
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure
SciELO journals
2019
Heart Failure
Sarcopenia
Sympathetic Hyperactivity
Blunted Vagal Reactivation.
2019-04-10 02:45:42
Dataset
https://scielo.figshare.com/articles/dataset/Sympatho-Vagal_Imbalance_is_Associated_with_Sarcopenia_in_Male_Patients_with_Heart_Failure/7974428
<div><p>Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.</p></div>