10.6084/m9.figshare.7974428.v1 Guilherme Wesley Peixoto da Fonseca Guilherme Wesley Peixoto da Fonseca Marcelo Rodrigues dos Santos Marcelo Rodrigues dos Santos Francis Ribeiro de Souza Francis Ribeiro de Souza Marcel Jose A. da Costa Marcel Jose A. da Costa Stephan von Haehling Stephan von Haehling Liliam Takayama Liliam Takayama Rosa Maria R. Pereira Rosa Maria R. Pereira Carlos Eduardo Negrão Carlos Eduardo Negrão Stefan D. Anker Stefan D. Anker Maria Janieire de Nazaré Nunes Alves Maria Janieire de Nazaré Nunes Alves Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure SciELO journals 2019 Heart Failure Sarcopenia Sympathetic Hyperactivity Blunted Vagal Reactivation. 2019-04-10 02:45:42 Dataset https://scielo.figshare.com/articles/dataset/Sympatho-Vagal_Imbalance_is_Associated_with_Sarcopenia_in_Male_Patients_with_Heart_Failure/7974428 <div><p>Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.</p></div>