%0 Generic %A RAMOS, Marcus Fernando Kodama Pertille %A PEREIRA, Marina Alessandra %A CHARRUF, Amir Zeide %A DIAS, André Roncon %A CASTRIA, Tiago Biachi de %A BARCHI, Leandro Cardoso %A RIBEIRO-JÚNIOR, Ulysses %A ZILBERSTEIN, Bruno %A CECCONELLO, Ivan %D 2019 %T CONVERSION THERAPY FOR GASTRIC CANCER: EXPANDING THE TREATMENT POSSIBILITIES %U https://scielo.figshare.com/articles/dataset/CONVERSION_THERAPY_FOR_GASTRIC_CANCER_EXPANDING_THE_TREATMENT_POSSIBILITIES/8091827 %R 10.6084/m9.figshare.8091827.v1 %2 https://scielo.figshare.com/ndownloader/files/15093662 %2 https://scielo.figshare.com/ndownloader/files/15093665 %2 https://scielo.figshare.com/ndownloader/files/15093668 %2 https://scielo.figshare.com/ndownloader/files/15093671 %2 https://scielo.figshare.com/ndownloader/files/15093674 %K Stomach neoplasms %K Neoadjuvant therapy %K Gastrectomy %X

ABSTRACT Background: Conversion therapy in gastric cancer (GC) is defined as the use of chemotherapy/radiotherapy followed by surgical resection with curative intent of a tumor that was prior considered unresectable or oncologically incurable. Aim: To evaluate the results of conversion therapy in the treatment of GC. Methods: Retrospective analysis of all GC surgeries between 2009 and 2018. Patients who received any therapy before surgery were further identified to define the conversion group. Results: Out of 1003 surgeries performed for GC, 113 cases underwent neoadjuvant treatment and 16 (1.6%) were considered as conversion therapy. The main indication for treatment was: T4b lesions (n=10), lymph node metastasis (n=4), peritoneal carcinomatosis and hepatic metastasis in one case each. The diagnosis was made by imaging in 14 cases (75%) and during surgical procedure in four (25%). The most commonly used chemotherapy regimens were XP and mFLOX. Major surgical complications occurred in four cases (25%) and one (6.3%) died. After an average follow-up of 20 months, 11 patients (68.7%) had recurrence and nine (56.3%) died. Prolonged recurrence-free survival over 40 months occurred in two cases. Conclusion: Conversion therapy may offer the possibility of prolonged survival for a group of GC patients initially considered beyond therapeutic possibility.

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