Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery Shiva Taghe Shahla Mirzaeei 10.6084/m9.figshare.9696776.v1 https://scielo.figshare.com/articles/dataset/Preparation_and_characterization_of_novel_mucoadhesive_ofloxacin_nanoparticles_for_ocular_drug_delivery/9696776 <div><p>The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery.</p></div> 2019-08-21 02:43:23 Ocular drug delivery Nanoparticles Corneal penetration Ofloxacin Chitosan