10.6084/m9.figshare.9739451.v1
Juliana Carvalho Romagnolli Plastina
Juliana Carvalho Romagnolli
Plastina
Vitor Y. Obara
Vitor Y.
Obara
Décio Sabbatini Barbosa
Décio Sabbatini
Barbosa
Helena Kaminami Morimoto
Helena Kaminami
Morimoto
Edna Maria Vissoci Reiche
Edna Maria Vissoci
Reiche
Andrea Graciano
Andrea
Graciano
Vinicius Daher Alvares Delfino
Vinicius Daher Alvares
Delfino
Functional iron deficiency in patients on hemodialysis: prevalence, nutritional assessment, and biomarkers of oxidative stress and inflammation
SciELO journals
2019
Renal Insufficiency, Chronic
Anemia, Iron-Deficiency
Oxidative stress
Inflammation
Nutrition Assessment
2019-08-28 02:44:33
Dataset
https://scielo.figshare.com/articles/dataset/Functional_iron_deficiency_in_patients_on_hemodialysis_prevalence_nutritional_assessment_and_biomarkers_of_oxidative_stress_and_inflammation/9739451
<div><p>Abstract Introduction: Anemic patients with chronic kidney disease (CKD) can be divided into anemic patients without or with functional iron deficiency (FID). The increase in the number of cases of hemosiderosis in patients on hemodialysis (HD) attributed to excessive intravenous iron replacement has called for the investigation of the factors involved in the genesis of FID. Objectives: This study aimed to describe the prevalence of FID in patients with CKD on HD, characterize the included individuals in terms of clinical and workup parameters, and assess their nutritional, oxidative stress, and inflammation statuses. This cross-sectional study assembled a convenience sample of 183 patients with CKD on HD treated in Southern Brazil. Patients meeting the inclusion and exclusion criteria were divided into two groups, one with anemic subjects with FID and one with anemic patients without FID. Participants answered a questionnaire probing into socio-epidemiological factors, underwent anthropometric measurements, and were tested for markers of anemia, oxidative stress, inflammation, and nutrition. Statistical analysis: The date sets were treated on software package GraphPad InStat version 3.1. Variables were tested with the Kolmogorov-Smirnov, chi-square, Student’s t, and Mann-Whitney tests. Statistical significance was attributed to differences with a p < 0.05. Results: Markers of inflammation were not statistically different between the two groups. Markers of anemia and nutrition were significantly lower in patients with FID. Patients with FID were prescribed higher doses of parenteral iron (p < 0,05). Discussion: FID was associated with lower nutritional marker levels, but not to increased levels of markers of inflammation or oxidative stress, as reported in the literature. Additional studies on the subject are needed.</p></div>