Carmo, Hercules Magalhães Olivense do Souza, Feliph Miquéias Alcântara de Soares, Ana Clara Leal Munhoz, João Abner Marins Santos, Francisco Glauco de Araújo de Siqueira, Nilton Ghiotti Silva, Romeu Paulo Martins Dietary supplementation with Camu-Camu versus sleeve gastrectomy in Wistar rats weight control. <p></p><p>ABSTRACT Objective: to compare the effects of the hydroalcoholic extract from the peel of Camu-Camu, a fruit plant belonging to the Myrtaceae family, widely distributed in the Amazon basin, with those of sleeve gastrectomy, on the weight and glycemia of Wistar rats. Methods: twenty-four Wistar rats underwent obesity induction through a hyperlipid diet for eight weeks (fat period), and were randomized into three groups: Control Group (CG), Camu-Camu Group (CCG) and Bariatric Surgery Group (BSG). After this period, all animals returned to a normal diet and the intervention period began: CG did not undergo any intervention beyond diet change; CCG animals underwent gavage procedure for administration of Camu-Camu hydroalcoholic extract, 1g/kg/day, for four weeks; and the BSG was submitted to the surgical procedure of sleeve gastrectomy. We followed all animals for four weeks. Results: there was only one loss in BSG due to a gastric fistula. We observed significant variations in the animals’ mean weight: the CG evolved with weight gain even after the withdraw of the hypercaloric diet, while the other two groups presented weight reduction. BSG presented a significant reduction of weight and BMI (p<0.05); CCG achieved a significant reduction only of the BMI (p<0.05). There were no statistically significant changes in the glycemic levels. Conclusion: in spite of reducing weight, the crude hydroalcoholic extract of the Camu-Camu peel was not able to be as efficient as sleeve gastrectomy in the control of body weight in Wistar rats.</p><p></p> Obesity;Gastrectomy;Bariatric Surgery;Phytotherapy;Rats, Wistar 2019-09-11
    https://scielo.figshare.com/articles/dataset/Dietary_supplementation_with_Camu-Camu_versus_sleeve_gastrectomy_in_Wistar_rats_weight_control_/9795914
10.6084/m9.figshare.9795914.v1