10.6084/m9.figshare.9796052.v1
Sandra Augusta de Moura LEITE
Sandra Augusta de Moura
LEITE
Rosana Costa CASANOVAS
Rosana Costa
CASANOVAS
Vandilson Pinheiro RODRIGUES
Vandilson Pinheiro
RODRIGUES
Adriana de Fátima Vasconcelos PEREIRA
Adriana de Fátima Vasconcelos
PEREIRA
Teresa Cristina Alves FERREIRA
Teresa Cristina Alves
FERREIRA
Flávia Raquel Fernandes do NASCIMENTO
Flávia Raquel Fernandes do
NASCIMENTO
Johnny Ramos do NASCIMENTO
Johnny Ramos do
NASCIMENTO
Isaac Suzart GOMES-FILHO
Isaac Suzart
GOMES-FILHO
Marcus Gomes BASTOS
Marcus Gomes
BASTOS
Antonio Luiz Amaral PEREIRA
Antonio Luiz Amaral
PEREIRA
The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels
SciELO journals
2019
Chronic Periodontitis
Hepcidins
Iron
Inflammation
2019-09-11 02:45:03
Dataset
https://scielo.figshare.com/articles/dataset/The_effect_of_nonsurgical_periodontal_therapy_on_hepcidin_and_on_inflammatory_and_iron_marker_levels/9796052
<div><p>Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30–65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.</p></div>