10.6084/m9.figshare.9796052.v1 Sandra Augusta de Moura LEITE Sandra Augusta de Moura LEITE Rosana Costa CASANOVAS Rosana Costa CASANOVAS Vandilson Pinheiro RODRIGUES Vandilson Pinheiro RODRIGUES Adriana de Fátima Vasconcelos PEREIRA Adriana de Fátima Vasconcelos PEREIRA Teresa Cristina Alves FERREIRA Teresa Cristina Alves FERREIRA Flávia Raquel Fernandes do NASCIMENTO Flávia Raquel Fernandes do NASCIMENTO Johnny Ramos do NASCIMENTO Johnny Ramos do NASCIMENTO Isaac Suzart GOMES-FILHO Isaac Suzart GOMES-FILHO Marcus Gomes BASTOS Marcus Gomes BASTOS Antonio Luiz Amaral PEREIRA Antonio Luiz Amaral PEREIRA The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels SciELO journals 2019 Chronic Periodontitis Hepcidins Iron Inflammation 2019-09-11 02:45:03 Dataset https://scielo.figshare.com/articles/dataset/The_effect_of_nonsurgical_periodontal_therapy_on_hepcidin_and_on_inflammatory_and_iron_marker_levels/9796052 <div><p>Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30–65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.</p></div>