10.6084/m9.figshare.9870395.v1
Isabela Cristina de Souza Marques
Isabela Cristina de Souza
Marques
Stefânia Bovo Minto
Stefânia Bovo
Minto
Mariane Quaglio Marques
Mariane Quaglio
Marques
Juliana Ribeiro
Juliana
Ribeiro
Paola Castro Moraes
Paola Castro
Moraes
Lourenço Sbragia Neto
Lourenço
Sbragia Neto
Sérgio Britto Garcia
Sérgio Britto
Garcia
Botulinum toxin as a treatment for short bowel syndrome in rats
SciELO journals
2019
Short Bowel Syndrome
Botulinum Toxins
Ileum
Rats
2019-09-18 03:30:54
Dataset
https://scielo.figshare.com/articles/dataset/Botulinum_toxin_as_a_treatment_for_short_bowel_syndrome_in_rats/9870395
<div><p>Abstract Purpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine. Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control). Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection. Conclusion: This may provide a new promising approach to the surgical treatment of SBS.</p></div>