10.6084/m9.figshare.9985874.v1
Tayssia Beatriz dos Santos
Tayssia Beatriz dos
Santos
Helena Korres de Paula
Helena Korres de
Paula
Marly Aparecida Spadotto Balarin
Marly Aparecida Spadotto
Balarin
Roseane Lopes Silva-Grecco
Roseane Lopes
Silva-Grecco
Marco Fábio Prata Lima
Marco Fábio Prata
Lima
Elisabete Aparecida Mantovani Rodrigues de Resende
Elisabete Aparecida Mantovani Rodrigues de
Resende
Mariana Kefalas Oliveira Gomes
Mariana Kefalas Oliveira
Gomes
Mariangela Torreglosa Ruiz Cintra
Mariangela Torreglosa Ruiz
Cintra
Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
SciELO journals
2019
Polycystic ovary syndrome
folic acid
polymorphism
2019-10-16 02:46:40
Dataset
https://scielo.figshare.com/articles/dataset/Can_the_genetic_polymorphisms_of_the_folate_metabolism_have_an_influence_in_the_polycystic_ovary_syndrome_/9985874
<div><p>ABSTRACT Objective To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Subjects and methods This study included 203 women (99 women with PCOS and 104 controls). The genotyping was performed by PCR-RFLP. Chi-squared test and multiple logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the SNPstat program. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p ≤ 0.05). Results The genotypic distribution of the RFC-1 A80G polymorphism showed significant difference between the two groups, showing that the heterozygous genotype (AG genotype) was most frequent in controls. The polymorphic homozygous (GG genotype) of MTRR A66G polymorphism were most frequent in controls. The T-C haplotype MTHFR C677T and A1298C polymorphisms were more frequent in the control group (OR = 0.19; CI 95% — 0.04 to 0.93 e p = 0.042). The multivariate analysis evidenced that family history of PCOS was more frequent in the PCOS group (OR = 3.29; CI 95% — 1.48 to 7.31; p = 0.003). Conclusion In our casuistry, the polymorphic homozygous of MTRR A66G polymorphism gene and heterozygous of RFC-1 A80G polymorphism gene, the haplotype T-C C677T and A1298C polymorphisms of MTHFR gene, can be associated with protective factors for the disease.</p></div>