10.6084/m9.figshare.9986294.v1
Thiago Hota
Thiago
Hota
Fernando Lorenzini
Fernando
Lorenzini
Eduardo Felippe Melchioretto
Eduardo Felippe
Melchioretto
Marcelo Zeni
Marcelo
Zeni
Djanira Aparecida da Luz Veronez
Djanira Aparecida da Luz
Veronez
Rogério de Fraga
Rogério de
Fraga
Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging process
SciELO journals
2019
Elastic Tissue
Erectile Dysfunction
Aging
Rats
2019-10-16 02:59:46
Dataset
https://scielo.figshare.com/articles/dataset/Stereological_analysis_of_elastic_fibers_of_the_corpus_cavernosum_of_rats_during_the_aging_process/9986294
<div><p>Abstract Purpose To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. Methods Forty-eight rats, raised under similar conditions, were subjected to the natural aging process and divided into four groups (G1 to G4), according to age at the time of penectomy (6, 9, 12, and 24 months, respectively). Histological sections of the middle segment of the penis were stained with Weigert’s resorcin-fuchsin, and the volumetric density (Vv) of elastic fibers of the corpora cavernosa were determined via stereological analysis. Results There were no statistically significant differences in Vv among groups G1, G2, and G3. These three groups were therefore considered as a single group. The mean Vv of this group showed a statistically significant reduction compared to that of G4 (0.16 vs. 0.11, p<0.05). Conclusion Natural aging in rats was responsible for a reduction in volumetric density of elastic fibers of the corpora cavernosa (approximately 30% decrease in Vv) during senescence.</p></div>