Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure Xu Li Daokang Xiang Yizhu Shu Xiangjun Zeng Yonghong Li 10.6084/m9.figshare.9986555.v1 https://scielo.figshare.com/articles/dataset/Mitigating_effect_of_tanshinone_IIA_on_ventricular_remodeling_in_rats_with_pressure_overload-induced_heart_failure/9986555 <div><p>Abstract Purpose To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 and 20 mg/kg TIIA groups. Ten rats receiving laparotomy excepting abdominal aortic coarctation were enrolled in sham-operated group. The 5, 10 and 20 mg/kg TIIA groups were treated with 5, 10 and 20 mg/kg TIIA, respectively, for 8 weeks. Results Compared with model group, in 20 mg/kg TIIA group the left ventricular ejection fraction, left ventricular fractional shortening, left ventricular systolic pressure, ±maximum left ventricular pressure rising and dropping rate, and myocardial B-cell lymphoma-2 and cleaved cysteinyl aspartate specific proteinase-3 protein levels were increased, respectively (P<0.05), and the left ventricular end diastolic diameter, left ventricular end systolic diameter, left ventricular end diastolic pressure, heart weight index, left ventricular weight index, serum B-type brain natriuretic peptide, interleukin 6 and C-reactive protein levels and myocardial B-cell lymphoma-2 associated X protein level were decreased, respectively (P<0.05). Conclusion TIIA may alleviate ventricular remodeling in rats with pressure overload-induced heart failure heart by reducing inflammatory response and cardiomyocyte apoptosis.</p></div> 2019-10-16 03:05:32 Tanshinone Ventricular Remodeling Heart Failure Myocytes, Cardiac Apoptosis Rats