Alterations induced in the ileum of mice upon inoculation with different species of Leishmania: a preliminary study

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posted on 2018-08-22, 02:56 authored by Amanda Gubert Alves dos Santos, Jéssica de Paula Ferlini, Suellen Lais Vicentino, Maria Valdrinez Campana Lonardoni, Debora de Mello Gonçales Sant’Ana, Gessilda de Alcântara Nogueira de Melo

Abstract INTRODUCTION: Leishmania species cause skin, mucosal, and disseminated lesions. We studied the effects of three Leishmania species on ileal morphology in mice. METHODS: BALB/c mice were intraperitoneally inoculated with Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) major (4 animals/group). After 72h, the ilea were collected and histologically processed. RESULTS: Following inoculation, the goblet cell and intraepithelial lymphocyte populations increased, while Paneth cell number and crypt width decreased. In addition, enterocyte size, villi height, and mucosa, submucosa, and muscular tunic thickness increased. CONCLUSIONS: Leishmania modified the quantity of cells in and morphology of mice ilea.