posted on 2019-06-05, 02:52authored byAlena Mileo Monteiro Diniz, Danielle Cristinne Azevedo Feio, Aniel de Sarom Negrão Silva, Rommel Rodríguez Burbano, Patrícia Danielle Lima de Lima
Abstract INTRODUCTION: The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. METHODS: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. RESULTS: Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. CONCLUSIONS: No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.