PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND CONTROLLED RELEASE OF GALACTOMANNAN MICROPARTICLES CONTAINING ALLANTOIN

In this work, the allantoin was encapsulated with galactomannan extruded from Delonyx regia, by the spray drying technique. The microparticles obtained were structurally characterized by infrared spectroscopy (IR), thermal analysis, scanning electron microscopy (SEM) and the controlled release profile was evaluated. The results of IR suggested the formation of the polymeric wall of the microcapsules and SEM revealed spherical particles with an average size range of 2.84 ± 0.41 µm. X-ray diffraction showed the loss of crystallinity of the active after encapsulation and differential explanatory calorimetry exhibited the loss of its peak melt. The encapsulation efficiency for the microparticles was approximately 84% for the different environmental conditions. The coating of allantoin with the biopolymer promoted a gradual release of the drug over a period of 6 hours and these results are in accordance with the Brazilian Pharmacopoeia. The set of results obtained in this work is relevant and accredits the system developed as a possible alternative for the formation of encapsulated natural drugs destined to possible treatments of cutaneous cellular regeneration.