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Prognostic factors for response to chemotherapy in advanced tumors of the uterine cervix: the role of neoangiogenesis.

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posted on 2019-02-20, 02:48 authored by Cláudio Franco do Amaral Kfouri, Welington Lombardi, Maria Clara Ferreira Nonato Romania, Matheus Lopes Puls, Rodrigo Amaral Martins-Ferreira, Luciana Borges Lombardi, Jurandyr Moreira de Andrade

ABSTRACT Objective: to analyze the expression of Vascular Endothelial Growth Factor (VEGF), its receptor (VEGFR-2), age and histological type of advanced cervical carcinomas with respect to the clinical response to neoadjuvant chemotherapy. Methods: we studied 40 patients with cervical carcinoma (IB2 and IVA) diagnosed by biopsies prior to treatment. All patients underwent neoadjuvant chemotherapy and evaluation for clinical response and expression of VEGF. We considered a tumor regression greater than 50% as a good clinical response. Results: eighteen patients (45%) had good response to chemotherapy, and 22 (55%), poor response. VEGF expression was positive in 16 patients and negative in 24. When analyzed separately for response to chemotherapy, only the positive expression of VEGF was associated with good clinical response (p=0.0157). Conclusion: VEGF expression alone was an important marker of good response to neoadjuvant chemotherapy in patients with advanced carcinoma of the cervix.

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    Revista do Colégio Brasileiro de Cirurgiões

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