posted on 2019-08-21, 02:47authored byAldicéia Luiz de Moura, Bruna Martins Guimarães, Josefa Aqueline da Cunha Lima, Mauricélia M. Sousa Mata, Jadson Farias da Silva, Ronaldo N. Oliveira, Juliano Carlo Rufino de Freitas, João R. de Freitas Filho
Amino sugars are chemical compounds that have a sugar backbone, in which one of the hydroxyl groups is replaced by an amino group. Derivatives of amine-containing sugars, such as N-acetylglucosamine, are also considered amino sugars. The synthetic introduction of amino functionalities in a regio- and stereoselective manner ontosugar scaffolds represents a substantial challenge. Most of the modern methods for the preparation of 1-, 2- and 3-amino sugars are those starting from glycals, 2,3-unsaturated O-glycosides epoxy-sugars, keto-sugars among others. This review summarizes recente developments in the current state of knowledge concerning the occurrence, biosynthesis, synthesis and application of amino sugars.