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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region
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posted on 2019-08-14, 02:51 authored by Rafael Affini Martins, Dandara Cassu-Corsi, Carolina Silva Nodari, Rodrigo Cayô, Larissa Natsumeda, Ana Paula Streling, André Mario Doi, Roberto José Carvalho da Silva, Roberta Alessandra Lima Bocalon, Ana Cristina Gales, Antonio Carlos Campos PignatariA total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).
