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Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays

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posted on 2019-08-21, 02:45 authored by José Darlan Alves da Silva, Cláudio Rodrigo Nogueira, Maria do Carmo Vieira, Silvia Cristina Heredia-Vieira, Alexeia Barufatti, Bruno do Amaral Crispim, Luiza Flávia Veiga Francisco, Lucilene Finoto Viana, Claudia Andrea Lima Cardoso

ABSTRACT: The aqueous extract of Aristolochia triangularis leaves showed activity against Artemia salina larvae, with an LD50 of 370.6 µg/mL. In experiments with Allium cepa seeds, the extract caused a 51.26% reduction in the germination index, inhibited mean root growth, and was cytotoxic at concentrations of 668 and 2,000 µg/mL. Its antioxidant activity was additionally assessed in this research and the ferric reducing antioxidant power value was found to be 391.2 µM/g. Such health-beneficial property can be attributed partly to the total phenolic content, spectrophotometrically determined as 52.67 mg/g. The occurrence of cytotoxicity suggested caution when consuming teas from A. triangularis leaves for medicinal purposes, and equally reveals the need for further studies to investigate their adverse effects.

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