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\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table_1 5 Author/year! Fluoride dose administered ResultsF Paul, Ekambaram, Jayakumar (1998)62* 20 or 40 mgF/kg in female rats for 60 daysJ Dose-dependent reduction on spontaneous motor activity; motor coordination did not present changes; loss of weight gain (dose-dependent); decreased total plasma, liver and skeletal muscle protein concentration; decreased cholinesterase activity in the blood, but acetylcholinesterase activity in the nervous system remained normalE Collins and collaborators (1995)63w 10 to 250 ppm of fluoride in female rats for evaluation of fetal development up to the 20th day of gestation There were no differences in relation to the control group; the groups that consumed 250 ppm of fluoride showed a decrease in food and water intake; fluoride showed no teratogenicityF Trabelsi, Guermazi, Zeghal (2001)644 500 mgF/L in the drinking water of female rats from the 15th day of gestation until birth. The objective was to evaluate the possible influence of fluoride on the development and functioning of the thyroid gland of the pups, who continued to receive treatment until the 14th day of life Animals receiving NaF had a 75% decrease in plasma free T4 (thyroxine); fluoride was able to cause a strong reduction in the hormone thyroxine, and this could be related to the histological changes and apoptosis observed in the cerebellum of these animals; Ekambaram, Paul (2001)65C 500 ppm in water. Female adult Wistar rats were treated for 60 days> Animals treated with NaF showed increased plasma concentration, decreased food intake with a consequent reduction in body weight gain, impairment of exploratory motor activity and motor coordination, dental injuries, inhibition of total cholinesterase activity in the blood, brain acetylcholinesterase and hypocalcemiaF Mullenix and collaborators (1995)66/ 75 to 125 ppm of fluoride for six weeks in rats After a three-week interval, they had plasma levels of 0.059 to 0.640 ppm of fluoride, similar to those reported in humans exposed to 5-10 ppm of fluoride. Animals treated with higher concentrations of NaF also showed a behavioral pattern rupture when exposed to a new environment; Peng, Xu, Zhang (2016)673 50, 100 and 150 mgF/L in rat embryonic cancer cells- Reduction of cell viability and damage to DNA@ Chen e colaboradores (2016)68t 50 mgF/L in different frog species to asses the effect of fluorine on growth, metamorphosis and skeletal developmentg Fluoride caused an increase in mortality, inhibition of metamorphosis and delay in skeletal development
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