ࡱ >
\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table_1 5 Author, year Study design Sample size (Brazil) Gene analyzed Analysis method Results Reference4 Teive et al., 2001 Family study 10 SNCA PCR-RFLP No pathogenic mutations found [7]4 Rawal et al., 2003 4 PRKN Sequencing and PCR-RFLP2 PRKN: Ex4 del - 1, Ex6 del - 1, pAsn52* - 1 [8]> Bertolli-Avella et al., 2005 Mutation screening [9]8 Clarimon et al., 2005 6
Sequencing PRKN: Ex4 del - 1 [10]7 DiFonzo et al., 2005 9 LRRK2 LRRK2: pG2019S - 1 [11]8 Bonifati et al., 2005 8 PINK1 [12]4 Khan et al., 2005 PRKN: Ex4 del - 6 [13]5 Chien et al., 2006 PRKN, PINK1, DJ1 PRKN: IVS1+1G/T - 10 [14]7 DiFonzo et al., 2006 [15]7 DiFonzo et al., 2007 92 ATP13A2 ATP13A2: pGly504Arg - 1 [16]6 Lesage et al., 2007 ND PRKN: Prom+Ex1 del - 1 [17]6 Aguiar et al., 2008 72 PRKN, LRRK2 Sequencing and qPCRq LRRK2: pG2019S - 4; PRKN: Ex3 del/N58QfsX39 - 4, pK211N - 1, Ex11 del/A390EfsX6 - 1, c1286-3G>C - 1 [18]6 Munhoz et al., 2008 83 LRRK2: p2019S - 6 [19]8 Pimentel et al., 2008 147 LRRK2: p2019S - 3 [20]J Santos-Rebouças et al., 2008 Case report / series 1 LRRK2: p2019S - 1 [21]> Godeiro-Junior et al., 2009 60 [22]: Barsottini et al., 2009 119 [23]8 Camargos et al., 2009 53 SNCA, PRKN, LRRK2, PINK1