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\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table_1 P A Author, year Study design Population Intervention
Target Main clinical findings PEDro score Class of evidence5 Khedr et al., 2020- Double-blind sham-controlled randomized trial 33 PD with dementiaI 20 Hz rTMS (2000 pulses) in 15 sessions, at 90% RMT with figure-of-eight. Bilateral M1, hand area Significant improvement in UPDRS III (22% improvement at three-month follow-up: 61 ± 16.4 vs 48.4 ± 14); minor but significant improvement in cognitive tests (MoCA 16.33 ± 4.23 vs 17.50 ± 3.93; MMSE 19.82 ± 2.71 vs 20.73 ± 3.17). 9 Class II7 Hanoglu et al., 2020 Randomized controlled trial 16 PD (pre-SMA and M1): 5 Hz rTMS (2000 pulses) in 10 sessions with circular coil.! Bilateral pre-SMA or bilateral M1 Significant UPDRS improvement (41%) only in pre-SMA group. (23.75 ± 7.57 vs 14.00 ± 5.47, one week after the end of stimulation). 5 Class IV4 Hill et al., 20208 Double-blind sham-controlled, crossover (washout 1 week) 14 PD` iTBS (2 s TBS trains every 10 s for 600 pulses) with figure-of-eight at 80% AMT, in one session.
Left DLPFC) No difference in cognitive tests or mood. 7 Class III Workman et al., 2020> Double-blind sham-controlled, crossover (washout of five days) 7 PD" 2 or 4 mA tDCS, in single session." Unilateral or bilateral cerebellar Significant improvement (p = 0.03) in Berg balance score in bilateral 4 mA group, versus no gait improvement in sham group. Four out of seven patients were considered responders due to their improvement in Berg Balance Score after one session. No longer follow-up was done. 85 Khedr et al., 2019 33 PD with dysphagiau 20 Hz rTMS (2000 pulses each side), in 10 sessions, at 90% RMT with figure-of-eight; five monthly follow-up sessions. Significant improvement in UPDRS III (26%) after three months of follow-up (61.9 ± 13.2 vs 45.8 ± 13.1; p = 0.0001), and in dysphagia scores; and reduction of swallowing time for solids, seen through videofluoroscopy. Sanna et al., 2019= Double-blind sham-controlled, crossover (washout of one week) 11 PD with dyskinesiasD cTBS (600 pulses) at 80% AMT, with circular coil, in single session.
Cerebellum7 Decrease in dyskinesias and serum BDNF in active group.6 Khedr et al., 2019b 52 PD (26 each group)V 20 Hz rTMS (at 90% RMT) or 1 Hz rTMS (at 100% RMT), with figure-of-eight; 2000 pulses. Bilateral M1 Improvement in UPDRS (24%) in both groups, compared with baseline, but longer-lasting in 20 Hz group (45.27 ± 20.01 vs 34.54 ± 13.02; one-month follow-up). Trung et al., 2019- Single-blind sham-controlled randomized trial" 28 PD with MCI (14 active 14 sham)a iTBS (2 s TBS trains every 10 s for 600 pulses) with figure-of-eight at 80% AMT, in six sessions. No difference in cognition between groups. In-group analysis showed improvement in attention, both in sham and in active group. Improvement in visuospatial function was only observed after active stimulation. 62 Mi et al., 2019&